Comparing aspirin and sulindac effects on breast density in women at high risk for breast cancer
Three-Arm randomized trial comparing the effect of aspirin, sulindac or no treatment control on breast density in patients with elevated breast cancer risk
This study is looking at how taking either aspirin or sulindac might change breast density in women who have a higher risk of breast cancer, and it will help us understand if these medications can affect breast tissue in a way that relates to cancer risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10819207 on NIH RePORTER |
What this research studies
This research investigates the effects of two non-steroidal anti-inflammatory drugs, aspirin and sulindac, on breast density in women who are at an elevated risk for breast cancer. Participants will be randomly assigned to receive either aspirin, sulindac, or no treatment, allowing researchers to compare the outcomes across these groups. The study aims to understand how these medications may influence breast tissue characteristics, which could be linked to breast cancer risk. By utilizing advanced imaging techniques, the research will assess changes in breast density and tissue composition over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women who have a higher risk of developing breast cancer.
Not a fit: Patients who are not at elevated risk for breast cancer or those who are not postmenopausal may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies for reducing breast cancer risk in women with elevated risk factors.
How similar studies have performed: Previous research has shown promising results with sulindac in reducing breast density, indicating potential for success in this study.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Thompson, Patricia Ann — State University New York Stony Brook
- Study coordinator: Thompson, Patricia Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.