Comparing a procedure to prevent strokes in older adults with atrial fibrillation and Alzheimer's disease to blood thinners.
Effectiveness and Safety of Transcatheter Left Atrial Appendage Occlusion vs. Anticoagulation in Older Adults with Atrial Fibrillation and Alzheimer's Disease and Related dementias
This study is looking at whether a one-time procedure called LAAO is a safer and more effective option than blood thinners for older adults with atrial fibrillation and Alzheimer's or related dementias, helping to prevent strokes without the risks that come with taking daily medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11105979 on NIH RePORTER |
What this research studies
This research investigates the effectiveness and safety of transcatheter left atrial appendage occlusion (LAAO) compared to traditional oral anticoagulants in older adults suffering from atrial fibrillation and Alzheimer's disease or related dementias. The study aims to address the challenges faced by these patients, who often cannot use blood thinners due to risks of falls and medication errors. By evaluating the outcomes of the LAAO procedure, which is a one-time treatment option, the research seeks to provide insights into a safer alternative for stroke prevention in this vulnerable population. The methodology includes analyzing patient data and outcomes to determine the best treatment approach for those with complex health needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who have atrial fibrillation and are also diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients who do not have atrial fibrillation or those without Alzheimer's disease and related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective stroke prevention option for older adults with atrial fibrillation and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results for transcatheter LAAO in other populations, but this specific approach for patients with dementia is relatively novel and underexplored.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lin, Joshua K — Brigham and Women's Hospital
- Study coordinator: Lin, Joshua K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.