Comparing a procedure to prevent strokes in older adults with atrial fibrillation and Alzheimer's disease to blood thinners.

Who could benefit from this research

What this research studies

This research investigates the effectiveness and safety of transcatheter left atrial appendage occlusion (LAAO) compared to traditional oral anticoagulants in older adults suffering from atrial fibrillation and Alzheimer's disease or related dementias. The study aims to address the challenges faced by these patients, who often cannot use blood thinners due to risks of falls and medication errors. By evaluating the outcomes of the LAAO procedure, which is a one-time treatment option, the research seeks to provide insights into a safer alternative for stroke prevention in this vulnerable population. The methodology includes analyzing patient data and outcomes to determine the best treatment approach for those with complex health needs.

Why it matters

Where this research is happening

• Brigham and Women's Hospital
  Boston, United States Active

Researchers

• Principal investigator: Lin, Joshua K — Brigham and Women's Hospital
• Study coordinator: Lin, Joshua K

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.