Comparing a monoclonal antibody to traditional immunosuppressive treatments for uveitis
ADalimumab Vs. conventional ImmunoSupprEssion for uveitis(ADVISE) Trial
This study is looking at how well adalimumab works compared to standard treatments for uveitis, an eye condition that can cause serious problems, to see which option helps people keep their vision better and with fewer side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10480091 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of adalimumab, a monoclonal antibody, compared to conventional immunosuppressive therapies for treating uveitis, a condition that causes inflammation in the eye and can lead to blindness. The study aims to determine which treatment approach provides better long-term visual outcomes while minimizing side effects. Patients will be monitored for their response to treatment, and the research will analyze data from multiple centers to ensure robust findings. By participating, patients may contribute to understanding how to improve care for those suffering from this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with non-infectious uveitis and require treatment.
Not a fit: Patients with infectious uveitis or those who do not meet the age criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with uveitis, potentially preserving their vision.
How similar studies have performed: Previous studies have shown that systemic immunosuppressive therapies can be effective for uveitis, suggesting that this approach may yield significant insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Holbrook, Janet T. — Johns Hopkins University
- Study coordinator: Holbrook, Janet T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.