Community-engaged research on HPV persistence and cervical cancer risk in Native American women
Official title: Full Project 1: Using Community-Engaged Research to Assess the Association of the Cervicovaginal Microenvironment and HPV Persistence and Clearance in Native American Women
Funded at Northern Arizona University · NIH-11405046 · Data updated 2026-11-12
A community-focused study aims to understand how the cervicovaginal environment relates to HPV persistence and cervical cancer risk in AI/AN women.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern Arizona University NIH-funded |
| Lab location | 1 site (Flagstaff, United States) |
| Project start | September 29, 2009 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $490,928 |
| NIH project number | 5U54CA143925-18 |
| Project ID | NIH-11405046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Native American women, particularly AIAN communities in Arizona, who are at risk for cervical HPV infection and cancer.
✕Less likely to help
Women without HPV infection or those not participating in sample collection may not directly benefit.
What this research studies
This project partners with Native American communities to study how the cervicovaginal microbiome and HPV infection interact, using 16S sequencing to profile microbes. It will recruit participants and collect samples to examine patterns of HPV persistence and clearance over time. The work seeks to translate microbiome findings into insights that could improve screening and prevention for AIAN women.
Why it matters
Potential benefit: Understanding microbiome factors linked to HPV persistence could lead to better risk stratification and targeted prevention for AIAN women.
How similar studies have gone: Prior work shows a link between vaginal microbiota and HPV dynamics, but AIAN-specific data are limited; this study builds on emerging evidence.
Where this research is happening
-
Northern Arizona University
Flagstaff, United States Active
Researchers
- Principal investigator: Lee, Naomi — Northern Arizona University
- Study coordinator: Lee, Naomi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.