Combining two drugs to reduce brain damage after injury
Official title: Preclinical Evaluation of Combination Therapy of Rolipram and Minocycline for Arresting Secondary Injury Cascade After Traumatic Brain Injury
Funded at Louisiana Tech University · NIH-10057824 · Data updated 2026-11-12
This study is looking at whether a mix of two medications, Rolipram and Minocycline, can help protect the brain from further damage after a traumatic brain injury, using a special way to deliver the drugs directly to the brain, and it's aimed at finding better treatments for people who have experienced a TBI.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana Tech University NIH-funded |
| Lab location | 1 site (Ruston, United States) |
| Project start | September 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2020 |
| Award (this year) | $367,623 |
| NIH project number | 1R21NS114723-01A1 |
| Project ID | NIH-10057824 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a traumatic brain injury.
✕Less likely to help
Patients who have not suffered a traumatic brain injury or those with chronic neurological conditions may not benefit from this research.
What this research studies
This research investigates how a combination of two drugs, Rolipram and Minocycline, can help reduce the secondary injury that occurs after a traumatic brain injury (TBI). The study uses a novel delivery method to target the brain and aims to measure the effectiveness of this combination in preventing long-term neurological damage. Researchers will monitor various biological markers and brain activity in mice over a month to assess the impact of the treatment. The goal is to find a faster and more effective way to mitigate the harmful effects that follow a TBI.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce long-term neurological problems in patients who suffer from traumatic brain injuries.
How similar studies have gone: While the specific combination therapy is novel, similar approaches using multimodal treatments for brain injuries have shown promise in previous research.
Where this research is happening
-
Louisiana Tech University
Ruston, United States Active
Researchers
- Principal investigator: Murray, Teresa Ann — Louisiana Tech University
- Study coordinator: Murray, Teresa Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.