Combining therapies to improve treatment for endometrial cancer
Official title: Combination Therapies Targeting Insulin Signaling in Endometrial Cancer
Funded at New York University School of Medicine · NIH-11138080 · Data updated 2026-11-12
This study is looking at how mixing different treatments can help improve care for women with endometrial cancer, especially those who are overweight, by focusing on how insulin affects cancer growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $507,696 |
| NIH project number | 7R01CA279561-03 |
| Project ID | NIH-11138080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with endometrial cancer, especially those who are obese or have high insulin levels.
✕Less likely to help
Patients with endometrial cancer who are not obese or do not have insulin-related issues may not benefit from this research.
What this research studies
This research investigates how combining different therapies can enhance the effectiveness of treatments for endometrial cancer, particularly in patients with obesity. It focuses on the role of insulin signaling in cancer progression and aims to lower insulin levels to improve the response to existing cancer therapies. The approach includes using patient-derived tumor tissues and animal models to test the effectiveness of these combined treatments. By understanding how insulin affects tumor growth, the research seeks to develop better treatment strategies for patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with endometrial cancer, particularly those affected by obesity.
How similar studies have gone: Previous research has shown that targeting insulin signaling can improve cancer treatment outcomes, suggesting this approach may be promising.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Goncalves, Marcus Dasilva — New York University School of Medicine
- Study coordinator: Goncalves, Marcus Dasilva
Related research
Other NIH-funded projects on the same topics.
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Prognostic tools to guide adjuvant therapy for Black women after hysterectomy for endometrial cancer
A new project aims to create and validate easy-to-use tools that help doctors tailor post-surgery treatment for Black women with endometrial cancer.
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Understanding why guideline-concordant endometrial cancer treatment varies in high-risk groups
This project looks at why some patients with endometrial cancer don’t receive care that follows national guidelines, aiming to find ways to ensure more patients get the best-supported treatments.
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Targeting hormone resistance to prevent endometrial cancer
Aims to boost progesterone’s cancer-preventing effect in the lining of the uterus to stop cancer from developing in people at risk, especially those who are obese or young.
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Inhibiting AXL to Improve Treatment Response in Endometrial Cancer
A cancer treatment study is testing whether blocking AXL with batiraxcept together with standard chemotherapy can help people with certain aggressive uterine cancers respond better.
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Targeting HSPA Proteins to Help Women with Advanced or Recurrent Endometrial Cancer
Aims to test a drug called SHetA2 that may slow or stop growth of advanced endometrial cancer by targeting cancer-friendlier proteins, with a focus on reducing treatment toxicity.
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Endometrial Cancer SPORE: New strategies to prevent and treat endometrial cancer
A multi-institution program is testing new ways to prevent and treat endometrial cancer in people, with three linked projects and multiple cores to support translational research.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.