Combining therapies to improve bone health in postmenopausal women with osteoporosis
Official title: Combined Anabolic Therapy in Postmenopausal Osteoporosis
Funded at Massachusetts General Hospital · NIH-10977280 · Data updated 2026-11-12
This study is looking at a new way to help women after menopause who have osteoporosis by using a mix of treatments that help build bone and prevent it from breaking down, with the hope of improving bone strength and lowering the risk of serious fractures.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 23, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $587,840 |
| NIH project number | 1R21AR083567-01A1 |
| Project ID | NIH-10977280 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postmenopausal women diagnosed with osteoporosis who are at high risk for fractures.
✕Less likely to help
Patients who are not postmenopausal or those without osteoporosis may not benefit from this research.
What this research studies
This research investigates a new approach to treating postmenopausal osteoporosis by combining different therapies that stimulate bone formation and inhibit bone breakdown. The goal is to develop a treatment regimen that provides sustained benefits in bone density and reduces the risk of fractures, particularly hip fractures, which are common and dangerous for older adults. Patients will be monitored for changes in bone mineral density and overall bone health using advanced imaging techniques. The study aims to address the limitations of current osteoporosis treatments that only provide temporary benefits.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that significantly reduce the risk of fractures in postmenopausal women with osteoporosis.
How similar studies have gone: Previous research has shown promise in using combined therapies for osteoporosis, but this specific approach is novel and aims to enhance treatment efficacy.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Leder, Benjamin Z — Massachusetts General Hospital
- Study coordinator: Leder, Benjamin Z
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.