Combining targeted radiation therapies for advanced thyroid cancer treatment
Combination Radiopharmaceutical Therapy and External Beam Radiotherapy
This study is looking at a new way to treat late-stage metastatic thyroid cancer by using a combination of two types of radiation therapy to better target the cancer while protecting healthy tissue, and it's designed for patients who haven't had success with standard treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10919188 on NIH RePORTER |
What this research studies
This research investigates a new approach to treating late-stage metastatic thyroid cancer by combining radiopharmaceutical therapy (RPT) with external beam radiotherapy (XRT). The study aims to assess the safety and feasibility of this combined treatment, which targets tumor cells more precisely while minimizing damage to surrounding healthy tissues. Patients will receive a tailored treatment plan that quantifies potential toxicity, allowing for better management of side effects. The research will involve a phase I clinical trial to evaluate the effectiveness of this combination therapy in patients who may not respond well to traditional treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with differentiated thyroid cancer who have late-stage metastatic disease and are not likely to be effectively treated with radioiodine alone.
Not a fit: Patients with early-stage thyroid cancer or those who are not candidates for radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a more effective treatment option for patients with advanced thyroid cancer, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promising results with similar combined radiation therapies, indicating potential for success in this novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Sgouros, George — Johns Hopkins University
- Study coordinator: Sgouros, George
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.