Combining non-invasive brain stimulation with therapy for cocaine addiction
Augmenting cognitive-behavioral therapy with rTMS of the medial prefrontal and anterior cingulate cortices for the treatment of cocaine use disorder
['FUNDING_OTHER'] · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · NIH-10840324
Adults with cocaine use disorder will receive non-invasive brain stimulation alongside cognitive-behavioral therapy to try to reduce cocaine use.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10840324 on ClinicalTrials.gov |
What this research studies
You would come to an outpatient clinic for repeated sessions of transcranial magnetic stimulation (rTMS) using the H7 coil that reaches deeper prefrontal regions involved in craving and self-control. Sessions are given alongside standard cognitive-behavioral therapy and participants are randomly assigned to real or sham (placebo) stimulation without knowing which they receive. The trial is double-blind and monitors cocaine use, treatment response, and brain measures to understand who benefits. The goal in this phase is to test feasibility and early signals that adding rTMS helps reduce cocaine use.
Who could benefit from this research
Good fit: Adults aged 21 and older with a diagnosis of cocaine use disorder who can attend regular outpatient visits and participate in cognitive-behavioral therapy are the intended participants.
Not a fit: People with medical contraindications to rTMS (for example, certain implanted metal devices or a history of seizures), severe unstable psychiatric or medical problems, or inability to attend outpatient sessions may not be eligible or benefit.
Why it matters
Potential benefit: If successful, adding rTMS to therapy could lower cocaine use and improve treatment response for people with cocaine use disorder.
How similar studies have performed: Early, small studies suggest rTMS can help with cocaine use, but well-controlled sham trials measuring cocaine consumption are limited, so this approach is promising but not yet proven.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARTINEZ, DIANA M — NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- Study coordinator: MARTINEZ, DIANA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.