Combining neural stem cells and a protein to treat ischemic stroke
Combination treatment of ischemic stroke with perlecan DV and neural stem cells
This study is looking at a new way to help people recover from ischemic stroke by using special cells and a protein to protect the brain, and it aims to see if this treatment can improve recovery and brain health after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10915844 on NIH RePORTER |
What this research studies
This research investigates a new treatment approach for ischemic stroke by using neural stem cells (NSCs) and a protein fragment called perlecan domain V (DV). The goal is to administer NSCs during the sub-acute phase of stroke to protect the blood-brain barrier from damage caused by ischemia-reperfusion injury. The researchers have shown promising results in animal models, indicating that this combination therapy could improve neurological function and reduce damage to the brain. Patients may be monitored for improvements in recovery and overall brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced an ischemic stroke and are within the sub-acute phase of recovery.
Not a fit: Patients who have had a stroke for an extended period or those with other severe comorbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery outcomes for stroke patients by minimizing brain damage and enhancing neurological function.
How similar studies have performed: Previous research has shown success with similar approaches using stem cells for stroke treatment, but this specific combination is novel.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Lee, Jean-Pyo — University of California Riverside
- Study coordinator: Lee, Jean-Pyo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.