Combining mRNA and SOSIP-NP for HIV prevention and treatment
SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens
This research aims to find new ways to prevent and treat HIV using a combination of vaccine approaches.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11116941 on NIH RePORTER |
What this research studies
For decades, finding a protective vaccine or cure for HIV has been challenging, and this work seeks to change that. Researchers are developing a combined approach using mRNA technology and a specific protein (SOSIP-NP) to create a powerful immune response. The goal is to develop an effective treatment that could eventually be used in people to either prevent HIV infection or help control it in those already living with the virus. This involves understanding how these vaccines work to protect against the virus and reduce its presence in the body.
Who could benefit from this research
Good fit: This foundational research is for anyone who could benefit from future advancements in HIV prevention or treatment, including those at risk of infection or currently living with HIV.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this early-stage research, as it is not yet ready for human trials.
Why it matters
Potential benefit: If successful, this research could lead to new vaccines that prevent HIV infection or provide a functional cure for people living with HIV.
How similar studies have performed: While a fully protective HIV vaccine or functional cure remains elusive, this approach builds on promising new vaccine technologies like mRNA that have shown success in other areas.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Williams, Wilton B — Duke University
- Study coordinator: Williams, Wilton B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.