Combining MRI and clinical tests to predict outcomes in multiple myeloma treatment
Official title: A framework for integrating MR imaging and clinical tests for prediction of outcomes in multiple myeloma treatment
Funded at University of Michigan at Ann Arbor · NIH-10991020 · Data updated 2026-11-12
This study is looking to help people with multiple myeloma by using MRI scans along with lab test results to better predict how well different treatments will work for them, so they can receive more personalized care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $570,314 |
| NIH project number | 5R01CA278898-02 |
| Project ID | NIH-10991020 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with multiple myeloma who are undergoing treatment and have varying prognoses.
✕Less likely to help
Patients with other types of hematologic malignancies or those not receiving treatment for multiple myeloma may not benefit from this research.
What this research studies
This research aims to improve the prediction of treatment outcomes for patients with multiple myeloma by integrating MRI imaging with clinical test results. By analyzing the tumor's evolution through non-invasive MRI and various laboratory values, the study seeks to create a more accurate model for assessing patient prognosis. This approach could lead to personalized treatment plans that are better suited to individual patient needs, ultimately enhancing the management of this complex disease.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of treatment outcomes, allowing for tailored therapies that improve patient survival and quality of life.
How similar studies have gone: Previous research has shown promise in using imaging techniques alongside clinical data to enhance treatment predictions, indicating that this approach has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Zhou, Chuan — University of Michigan at Ann Arbor
- Study coordinator: Zhou, Chuan
Related research
Other NIH-funded projects on the same topics.
-
Integrative study of multiple myeloma genetics and disease biology
A team at Dana-Farber and partners is pursuing a long-term project to understand the genetic and molecular drivers of multiple myeloma and how treatments interact with disease biology.
-
Comparative Modeling to Prevent, Detect Early, and Treat Multiple Myeloma
A research team will build and compare computer models to understand how multiple myeloma develops, can be detected earlier, and treated more effectively.
-
How LDL Affects Multiple Myeloma: New Pathways to Keep Remission
A new grant is studying how cholesterol from LDL particles fuels multiple myeloma and how this interaction influences the tumor environment and immune response, with goals to help patients stay in remission.
-
Therapy-induced senescence and immune activation in multiple myeloma
A study in people with multiple myeloma will explore how treatment-related senescence in cancer cells may stimulate the immune system and affect cancer return after standard frontline therapy.
-
BCMA CAR-T enteritis: understanding immune toxicities in multiple myeloma
A broad study to uncover why some CAR-T cell treatments targeting BCMA cause severe intestinal inflammation in people with multiple myeloma.
-
Understanding Drug-Resistant Multiple Myeloma to Stop Relapse
Researchers are studying why some myeloma cells resist treatment and how to create new therapies to prevent relapse.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.