Combining mindfulness techniques with brain stimulation to treat depression
Mindfulness Engaged Neurostimulation for Depression (MEND)
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11079649
This study is exploring a new way to help people with hard-to-treat depression by using a mix of mindfulness exercises and a brain stimulation technique, hoping to boost their mental control and improve their overall well-being.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11079649 on ClinicalTrials.gov |
What this research studies
This research investigates a new approach to treating depression by combining digital mindfulness training with a brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS). The goal is to enhance cognitive control, which is often impaired in individuals with depression, particularly those who do not respond to standard treatments. Participants will engage in breath-focused attention training while receiving rTMS targeting a specific brain region associated with cognitive function. This innovative combination aims to improve treatment outcomes and overall quality of life for those suffering from treatment-resistant depression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with treatment-resistant depression who experience cognitive control deficits.
Not a fit: Patients with mild depression or those who have responded well to standard antidepressant treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a more effective treatment option for individuals with depression, particularly those who have not responded to traditional therapies.
How similar studies have performed: While the combination of mindfulness techniques and rTMS is a novel approach, previous studies have shown promise in using rTMS for depression, though with limited success rates.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MISHRA, JYOTI — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: MISHRA, JYOTI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.