Combining liver-directed and alcohol-use treatments for severe alcohol-related hepatitis
Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) - Indiana University Data Coordinating Center
This project tests giving immediate treatment for severe alcohol-associated hepatitis followed by support to reduce or stop drinking for people eligible for steroid therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11194377 on NIH RePORTER |
What this research studies
You would be part of a networked clinical trial that first treats the acute liver injury in severe alcohol-associated hepatitis and then provides interventions targeting alcohol use disorder. An Indiana University-based Data Coordinating Center runs the study infrastructure, organizes data collection, and maintains a biosample repository. Patients at participating hospitals are randomly assigned to integrated treatment approaches and followed for liver and drinking outcomes. The coordinated design helps compare results across sites and preserve samples for future research.
Who could benefit from this research
Good fit: Adults with severe alcohol-associated hepatitis who are eligible for steroid therapy and willing to engage in alcohol-use disorder treatment and follow-up are the intended candidates.
Not a fit: People without alcohol-associated liver disease, those not eligible for steroid treatment, or those unwilling to participate in alcohol-use interventions are unlikely to benefit from this trial.
Why it matters
Potential benefit: If successful, the combined approach could lower liver-related complications and deaths by treating the liver injury and the underlying alcohol use together.
How similar studies have performed: Steroids and separate alcohol-use treatments have shown some benefit individually, but testing them together in an integrated randomized trial is relatively new.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Tu, Wanzhu — Indiana University Indianapolis
- Study coordinator: Tu, Wanzhu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.