Combining anti-inflammatory treatment with stem cell therapy for brain injuries
Official title: Anti-inflammatory and hMSC combination therapy for traumatic brain injury
Funded at James a. Haley VA Medical Center · NIH-10950313 · Data updated 2026-11-12
This study is looking for better treatments for traumatic brain injury, especially for military personnel, by using special stem cells and anti-inflammatory medicines to help reduce swelling and improve healing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James a. Haley VA Medical Center NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | October 1, 2022 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX005757-03 |
| Project ID | NIH-10950313 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced moderate traumatic brain injuries, particularly those related to military service.
✕Less likely to help
Patients with severe traumatic brain injuries or those who do not meet the specific criteria for moderate TBI may not benefit from this research.
What this research studies
This research aims to develop effective therapies for traumatic brain injury (TBI), particularly focusing on military personnel who are at high risk. The approach involves using mesenchymal stem cells (MSCs) in combination with anti-inflammatory agents to enhance treatment efficacy. By studying an experimental mouse model that mimics human TBI, researchers are investigating how this combination can reduce inflammation and improve recovery outcomes. The goal is to find a safe and effective treatment for moderate TBI, which currently lacks FDA-approved options.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery from traumatic brain injuries.
How similar studies have gone: Previous research has shown promise in using stem cell therapies for brain injuries, but the combination with anti-inflammatory agents is a novel approach.
Where this research is happening
-
James a. Haley VA Medical Center
Tampa, United States Active
Researchers
- Principal investigator: Mohapatra, Subhra — James a. Haley VA Medical Center
- Study coordinator: Mohapatra, Subhra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.