Combining advanced radiation therapies for treating relapsed neuroblastoma in children
Official title: COMBINATION HIGH-LET MOLECULAR RADIOTHERAPY OF RELAPSED REFRACTORY NEUROBLASTOMA
Funded at Washington University · NIH-10979741 · Data updated 2026-11-12
This study is testing a new way to treat relapsed neuroblastoma in kids by using a special type of radiation therapy combined with targeted medicines that focus on cancer cells, hoping to make treatment more effective and get rid of any tiny cancer cells that other treatments might miss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $600,079 |
| NIH project number | 1R01CA285959-01A1 |
| Project ID | NIH-10979741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have been diagnosed with relapsed or refractory neuroblastoma.
✕Less likely to help
Patients with neuroblastoma that has not relapsed or those over the age of 11 may not benefit from this research.
What this research studies
This research focuses on developing a new treatment approach for relapsed neuroblastoma, a challenging childhood cancer. It aims to combine high linear energy transfer molecular radiotherapy with targeted agents that specifically attack cancer cells. By utilizing novel ligands that target specific biomarkers, the study seeks to improve the effectiveness of treatment and potentially eliminate microscopic cancer cells that traditional therapies may miss. The research will involve clinical trials to assess the safety and efficacy of this combination therapy in young patients.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates for children with relapsed neuroblastoma.
How similar studies have gone: Previous research has shown promising results with similar high-energy radiation therapies, indicating potential for success in this novel approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Zhang, Hanwen — Washington University
- Study coordinator: Zhang, Hanwen
Related research
Other NIH-funded projects on the same topics.
-
Combination high-LET radiotherapy for relapsed neuroblastoma in children
A new treatment approach uses high-linear-energy-transfer radiotherapy with novel ligands to target neuroblastoma that has returned or persisted in children.
-
A new combination radiation treatment for neuroblastoma that has returned or is hard to treat
This project aims to develop a new combination radiation treatment for children with neuroblastoma that has come back or is difficult to treat.
-
AI-powered radiotherapy planning for cervical and head-and-neck cancer
A computer program helps plan radiation therapy for cervical and head-and-neck cancer patients to make treatments faster and more accurate.
-
AI-powered radiotherapy planning for cervical and head-and-neck cancer
A United Kingdom study is testing AI software that helps plan radiotherapy for cervical and head-and-neck cancer patients to save time and reduce the workload for clinicians in low-resource settings.
-
AI-powered radiotherapy planning for cervical and head-and-neck cancer
A UK research team is testing an AI-based software to automatically outline cancer areas and plan radiation beams to speed up treatment for cervical and head-and-neck cancers in LMICs.
-
AI-Powered Radiotherapy Planning for Cervical and Head & Neck Cancer
A new AI tool helps plan radiation therapy for cervical and head-and-neck cancers to save time and reduce the need for specialized staff.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.