Combining a special vaccine with immunotherapy for recurrent ovarian cancer
A phase I/II study of combined therapy with Th17-inducing dendritic cells and pembrolizumab in patients with recurrent epithelial ovarian cancer
This research combines a unique vaccine with an immunotherapy drug to help patients with ovarian cancer that has returned.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11114072 on NIH RePORTER |
What this research studies
Ovarian cancer can be challenging to treat, especially when it comes back. Immunotherapy drugs, which help your body's immune system fight cancer, haven't always worked well on their own for this type of cancer. This project aims to boost the immune system's ability to fight ovarian cancer by first giving a special vaccine that targets cancer cells. This vaccine is designed to create a strong immune response, which we hope will then make the immunotherapy drug more effective in shrinking tumors.
Who could benefit from this research
Good fit: This opportunity is for patients who have recurrent epithelial ovarian cancer.
Not a fit: Patients whose ovarian cancer has not returned or who are not suitable for immunotherapy may not benefit from this specific approach.
Why it matters
Potential benefit: If successful, this combined approach could offer a new and more effective treatment option for patients with recurrent ovarian cancer.
How similar studies have performed: A previous early-stage clinical trial of the vaccine alone showed that it successfully generated strong immune responses in nearly all ovarian cancer patients.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Knutson, Keith L. — Mayo Clinic Jacksonville
- Study coordinator: Knutson, Keith L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.