Collecting small vesicles from blood to understand pediatric sepsis
Official title: Biobank of small extracellular vesicles for pediatric sepsis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10909309 · Data updated 2026-11-12
This study is looking at tiny particles in the blood of critically ill children to learn more about sepsis and how it affects their bodies, with the hope of finding better ways to diagnose and treat this serious condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 17, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $219,338 |
| NIH project number | 5R21GM151734-02 |
| Project ID | NIH-10909309 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients aged 0-11 years who are diagnosed with sepsis.
✕Less likely to help
Patients who are not critically ill or do not have a diagnosis of sepsis may not benefit from this research.
What this research studies
This research focuses on understanding sepsis in children by analyzing small extracellular vesicles (sEVs) found in blood samples. These vesicles can provide insights into the inflammatory responses associated with sepsis and help identify specific organ failures. By collecting and studying these vesicles from pediatric patients, researchers aim to uncover unique molecular signatures that could lead to personalized treatment strategies for sepsis. The study involves obtaining blood samples from critically ill children to explore the potential of sEVs as biomarkers for better diagnosis and treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and personalized treatment options for children suffering from sepsis.
How similar studies have gone: Previous research has shown promise in using extracellular vesicles as biomarkers in various conditions, suggesting potential success for this novel approach in pediatric sepsis.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Zingarelli, Basilia — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Zingarelli, Basilia
Related research
Other NIH-funded projects on the same topics.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
-
Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Role of MMP3 in heart dysfunction during sepsis
This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
-
Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.