Collecting small vesicles from blood to understand pediatric sepsis
Biobank of small extracellular vesicles for pediatric sepsis
This study is looking at tiny particles in the blood of critically ill children to learn more about sepsis and how it affects their bodies, with the hope of finding better ways to diagnose and treat this serious condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10909309 on NIH RePORTER |
What this research studies
This research focuses on understanding sepsis in children by analyzing small extracellular vesicles (sEVs) found in blood samples. These vesicles can provide insights into the inflammatory responses associated with sepsis and help identify specific organ failures. By collecting and studying these vesicles from pediatric patients, researchers aim to uncover unique molecular signatures that could lead to personalized treatment strategies for sepsis. The study involves obtaining blood samples from critically ill children to explore the potential of sEVs as biomarkers for better diagnosis and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients aged 0-11 years who are diagnosed with sepsis.
Not a fit: Patients who are not critically ill or do not have a diagnosis of sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and personalized treatment options for children suffering from sepsis.
How similar studies have performed: Previous research has shown promise in using extracellular vesicles as biomarkers in various conditions, suggesting potential success for this novel approach in pediatric sepsis.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Zingarelli, Basilia — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Zingarelli, Basilia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.