Colaboración Evita: Preventing cervical cancer in Latin America
Colaboración Evita: Cervical Cancer Prevention Partnership Center
This project compares different HPV vaccine schedules for children with HIV and compares HPV testing versus Pap smears for cervical screening in women to find simpler, more effective prevention approaches.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11381343 on NIH RePORTER |
What this research studies
You could join one of two trials run at clinics in Peru, Brazil, Haiti, and the Dominican Republic. The vaccine trial compares immune responses to the 9-valent HPV vaccine using three-dose, two-dose, and single-dose schedules in children living with HIV, and looks at single-dose responses in children with versus without HIV. The screening trial compares switching from Pap smears (cytology) to HPV testing for primary cervical screening and tests new molecular triage methods for women who are HPV-positive, with special focus on women living with HIV. Study teams will complete lab assays, assemble and analyze the data, publish results, and share findings with clinicians and communities.
Who could benefit from this research
Good fit: Ideal candidates are children (including those living with HIV) for the vaccine trial and adult women — particularly women living with HIV — for the cervical screening trial at clinics in Peru, Brazil, Haiti, or the Dominican Republic.
Not a fit: People who are not in the target age groups, do not meet the trial's HIV-status criteria for specific arms, or who cannot attend clinics in the participating countries may not be eligible or see direct benefit.
Why it matters
Potential benefit: If successful, this work could simplify HPV vaccination schedules for children with HIV and improve cervical screening for women, especially those living with HIV, lowering the risk of HPV-related cancers.
How similar studies have performed: Previous research supports HPV-based screening and single-dose vaccine approaches in general populations, but these strategies are less well tested in children and women living with HIV, making these trials important for that gap.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Madeleine, Margaret M — Fred Hutchinson Cancer Center
- Study coordinator: Madeleine, Margaret M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.