Cognitive decline and dementia links in people with prediabetes and type 2 diabetes
Cognitive impairment in the DPPOS cohort and its neuropathologic, neurophysiologic, sociodemographic, and behavioral correlates
['FUNDING_OTHER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11367310
This work looks at brain markers, scans, and social and behavioral factors tied to memory and thinking changes in people with prediabetes or type 2 diabetes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11367310 on ClinicalTrials.gov |
What this research studies
If you take part, researchers will follow nearly 2,000 people from the Diabetes Prevention Program Outcomes Study to track memory and thinking changes over time. They will use blood tests that measure amyloid, tau, neurodegeneration, and inflammation, and a subgroup of about 650 people will get brain imaging for amyloid, cortical thickness, small vessel disease, white matter structure, and connectivity. The team will also consider sleep problems, depressive symptoms, and sociodemographic factors like race, sex, education, and literacy when looking at who develops mild cognitive impairment or dementia. The work aims to link biological, imaging, and social factors to the types of cognitive problems people experience.
Who could benefit from this research
Good fit: Adults with a history of prediabetes or type 2 diabetes—especially those who were part of the DPPOS cohort—are the focus of this work.
Not a fit: People without prediabetes or type 2 diabetes or those not connected to the DPPOS cohort are unlikely to be directly involved or benefit from this specific project.
Why it matters
Potential benefit: If successful, this could help identify which people with prediabetes or type 2 diabetes are at higher risk of memory loss and point to targets for prevention or earlier care.
How similar studies have performed: Previous research has linked prediabetes and type 2 diabetes to higher dementia risk and shown promising biomarker signals, but combining blood biomarkers, detailed imaging, neuropathology, and social/behavioral factors in a single large cohort is less common.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NOBLE, JAMES MCCALLUM — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: NOBLE, JAMES MCCALLUM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Alzheimer disease dementia