CoFAR food allergy clinical center
Consortium for food allergy research clinical center CoFar
This project tests whether giving helpful gut bacteria (microbiota transplantation), with or without tiny amounts of peanut, can make peanut allergy safer for teens.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11311285 on NIH RePORTER |
What this research studies
You would be joining a multi-site clinical network that runs trials and collects blood, stool, and other samples to study food allergy. The main trial planned here gives microbiota transplantation therapy (MTT) to teenagers with peanut allergy, sometimes combined with low-dose peanut oral immunotherapy, and monitors safety and allergic reactions over time. Lab teams will study immune responses, the gut microbiome, and metabolite changes to understand how the treatment might work and for whom. The network aims to recruit diverse participants and follow them at participating clinical centers across the consortium.
Who could benefit from this research
Good fit: Ideal candidates are teenagers with a confirmed peanut allergy who meet the study's health criteria and can attend visits at a participating center.
Not a fit: People without peanut allergy, those outside the trial age range, or individuals with medical conditions that make immunotherapy unsafe are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this could reduce allergic reactions or increase tolerance to peanut in teens with peanut allergy.
How similar studies have performed: An earlier phase I trial in adults showed promising results, but applying microbiota transplantation with or without oral immunotherapy in teens is still experimental.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Rachid, Rima — Boston Children's Hospital
- Study coordinator: Rachid, Rima
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.