Coatings to fight infection and inflammation around dental implants
Multifunctional Ionic Liquid Application for Treatment of Peri-implant Diseases
['FUNDING_R01'] · UNIVERSITY OF TEXAS DALLAS · NIH-11169903
A special implant coating designed to kill harmful bacteria and calm inflammation for people with infected or at-risk dental implants.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS DALLAS (nih funded) |
| Locations | 1 site (RICHARDSON, UNITED STATES) |
| Trial ID | NIH-11169903 on ClinicalTrials.gov |
What this research studies
I have or may get dental implants, and this project is developing a thin ionic liquid coating for titanium implants that aims to both remove bacteria and change the local immune response so tissues can heal. The team uses amino-acid based versions (for example, a phenylalanine formulation) that stick to implant surfaces and resist being scraped away. Most work so far is lab-based to show the coating prevents biofilm and preserves the metal surface without creating harmful particles. The long-term aim is to help implants re-integrate with surrounding tissue and reduce the chance of implant loss.
Who could benefit from this research
Good fit: People with signs of peri-implant mucositis or peri-implantitis, or patients about to receive dental implants who want added protection, would be the best candidates.
Not a fit: Patients with severe bone loss requiring implant removal or those with known allergies to implant or coating materials may not benefit from this approach.
Why it matters
Potential benefit: If successful, this could reduce infections, protect implant surfaces, lower chronic inflammation, and improve implant survival and healing.
How similar studies have performed: Early laboratory studies from the group showed stable, antibacterial coatings on titanium, but clinical benefits in people have not yet been demonstrated.
Where this research is happening
RICHARDSON, UNITED STATES
- UNIVERSITY OF TEXAS DALLAS — RICHARDSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RODRIGUES, DANIELI — UNIVERSITY OF TEXAS DALLAS
- Study coordinator: RODRIGUES, DANIELI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.