Coagulation monitoring to predict bleeding and guide transfusions during ECMO
Integrated Coagulation Sensing to Predict Hemorrhage and Guide Transfusions
Doctors are using a bedside device called iCoagLAB to help predict bleeding and clotting for people on ECMO.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11131568 on NIH RePORTER |
What this research studies
If you're on ECMO, this project would use a new hemostasis profiler called iCoagLAB to get frequent, bedside clotting measurements from small blood samples. The team will run prospective clinical studies in ECMO patients, comparing iCoagLAB readings to standard lab tests and tracking bleeding and clotting events. The device is intended to guide transfusion and anticoagulation decisions to avoid dangerous hemorrhage or clot formation. The goal is to reduce iatrogenic blood loss from frequent sampling and improve individualized management while on ECMO.
Who could benefit from this research
Good fit: Ideal candidates are patients currently receiving ECMO support (for cardiogenic shock, respiratory failure, or similar indications) at participating hospitals.
Not a fit: People who are not on ECMO or who are treated at hospitals not participating in the trial would not be eligible or likely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could reduce life-threatening bleeding and dangerous clots in ECMO patients and lower the need for transfusions.
How similar studies have performed: Other bedside coagulation tools such as TEG and ROTEM have shown some benefit in guiding bleeding management, but using iCoagLAB specifically during ECMO is a newer approach under study.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Nadkarni, Seemantini K — Massachusetts General Hospital
- Study coordinator: Nadkarni, Seemantini K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.