Clinical tumor oxygen scanner
EPR scanner for tumor oximetry in the clinic
This project will build an easy-to-use scanner that measures how much oxygen is in tumors to help doctors plan treatment for people with cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11256773 on NIH RePORTER |
What this research studies
From a patient's view, the team will turn an experimental EPR oximetry method into a medical scanner that can be used in everyday clinics. They will work with a device company to design the scanner so clinic staff can make direct and repeated oxygen measurements from tumors. The device will be tested in human subjects for safety, reliability, and ease of use. The aim is to give doctors real-time tumor oxygen information so treatments such as radiotherapy can be timed for better effect.
Who could benefit from this research
Good fit: Ideal candidates are people with solid tumors who can visit a participating clinic and are receiving or planning to receive locoregional treatments such as radiotherapy.
Not a fit: People with blood cancers, tumors that cannot be accessed or measured by the scanner, or those not undergoing local treatments are unlikely to benefit from this device.
Why it matters
Potential benefit: If successful, this could help doctors pick better times to give radiation and improve treatment effectiveness while reducing side effects.
How similar studies have performed: Early clinical work by the Dartmouth EPR team has shown the method is safe and feasible in people, but translating it into a routine clinical scanner is a new step.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Kuppusamy, Periannan — Dartmouth College
- Study coordinator: Kuppusamy, Periannan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.