Clinical trial support for children with high-risk neuroblastoma
Translational, statistical, and clinical trials core
This program offers clinical trials of targeted drugs and immune-based treatments for children with high-risk or relapsed neuroblastoma.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11310019 on NIH RePORTER |
What this research studies
This core funds the clinical and statistical team that helps design, run, and analyze trials of molecular and immunotherapy combinations for high-risk neuroblastoma. It provides trial infrastructure, data expertise, and coordination across the NANT consortium so lab findings can move quickly into patient care. Trials use tumor profiling and biomarkers to try to match treatments to each child’s cancer biology. Children with resistant or relapsed disease are enrolled at participating pediatric cancer centers in the network.
Who could benefit from this research
Good fit: Children with high-risk, relapsed, or refractory neuroblastoma who meet trial-specific eligibility and can receive care at a participating pediatric cancer center.
Not a fit: Children with low-risk neuroblastoma, unrelated cancers, or those who do not meet trial eligibility due to medical reasons or prior treatments are unlikely to benefit from these trials.
Why it matters
Potential benefit: If successful, this work could bring new targeted and immune-based treatments that improve survival and reduce relapse for children with high-risk neuroblastoma.
How similar studies have performed: The NANT consortium has run dozens of trials enrolling over 1,400 patients and helped advance at least two therapies toward regulatory approval, though relapsed high-risk neuroblastoma remains difficult to cure.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Park, Julie R — Children's Hosp of Philadelphia
- Study coordinator: Park, Julie R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.