Clinical biobank and translational support for AML/MDS
Clinical Shared Resource
Collects and stores blood and bone marrow from people with AML or MDS to help scientists develop better treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11196546 on NIH RePORTER |
What this research studies
This program asks people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) to donate blood or bone marrow at diagnosis, remission, and relapse so samples can be linked to their clinical history. The core stores and annotates these biospecimens and shares them with research teams who test how leukemia cells respond to drugs and which proteins drive disease. Projects include studying anti‑apoptotic proteins like BFL‑1, effects on MYB, and new menin‑targeting therapies to understand and prevent treatment resistance. By using patient samples, the team aims to move promising lab findings toward new clinical options and ancillary studies.
Who could benefit from this research
Good fit: Adults with a diagnosis of AML or MDS who are willing to provide blood or bone marrow samples at specified timepoints (diagnosis, remission, relapse) are ideal candidates.
Not a fit: People without AML or MDS or those unwilling/unable to provide biospecimens are unlikely to directly benefit from participation.
Why it matters
Potential benefit: Could help identify more effective, targeted therapies for AML/MDS and strategies to prevent or overcome drug resistance.
How similar studies have performed: Biobanking and functional profiling have supported successful targeted treatments in some AML subtypes, but elements like novel menin degraders are still early and largely preclinical.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Deangelo, Daniel J — Dana-Farber Cancer Inst
- Study coordinator: Deangelo, Daniel J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.