Clinical and biological data support for people receiving lung transplants
Core B: Human and Clinical Phenotyping Core
['FUNDING_P01'] · NORTHWESTERN UNIVERSITY · NIH-11193889
This project collects detailed health information and blood and tissue samples from people receiving lung transplants to link clinical events like graft dysfunction to molecular changes.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11193889 on ClinicalTrials.gov |
What this research studies
If you join, the team will enroll lung transplant recipients and record detailed clinical events, including diagnoses of primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD). They will collect blood and tissue samples at planned times and when clinical complications occur, then prepare single-cell suspensions and preserved tissue for tests such as flow cytometry, single-cell RNA-sequencing with CITE-seq, and spatial transcriptomics. Researchers will combine these molecular measurements with clinical data over time and use machine learning to find biomarkers and biological pathways linked to transplant outcomes. The findings will guide laboratory experiments and future clinical trials aimed at preventing or treating graft dysfunction.
Who could benefit from this research
Good fit: Ideal candidates are adults receiving a lung transplant at a participating center who agree to clinical follow-up and periodic blood and tissue sampling.
Not a fit: People who are not lung transplant recipients, or who cannot provide samples or long-term follow-up, would not benefit directly from participation.
Why it matters
Potential benefit: This work could help identify early markers and biological targets to prevent or treat graft injury and long-term transplant failure.
How similar studies have performed: Previous multi-omics and single-cell studies in transplant and immune diseases have revealed useful biomarkers, but applying longitudinal single-cell and spatial profiling specifically to lung transplant outcomes is relatively new.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGER, BENJAMIN DAVID — NORTHWESTERN UNIVERSITY
- Study coordinator: SINGER, BENJAMIN DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.