Cleveland vaccine protection and social factors for respiratory illnesses
Official title: RFA-IP-22-004, CORVETS - Cleveland Ohio Respiratory Viruses Vaccines Effectiveness across Traditional Risk Factors and Social Determinants of Health
Funded at University Hospitals of Cleveland · NIH-11146318 · Data updated 2026-11-12
This project follows people with flu, COVID-19, and other respiratory infections in the Cleveland area to learn how well vaccines protect them and how health and household factors matter.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University Hospitals of Cleveland NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,610,715 |
| NIH project number | 5U01IP001181-04 |
| Project ID | NIH-11146318 on NIH RePORTER |
Who could benefit from this research
✓Could help
People of any age who seek outpatient care in the Cleveland area for flu-like or COVID-like symptoms, including patients seen at University Hospitals, Case Western Reserve partners, and the Cleveland VA.
✕Less likely to help
People without respiratory symptoms, those not seeking outpatient care, or those living outside the recruitment area are unlikely to participate or benefit directly.
What this research studies
If you join, the team will enroll people who come to outpatient clinics with respiratory symptoms and collect health information and lab samples. They plan to enroll at least 1,000 patients each year and store clinical and laboratory data in an electronic repository. Testing will include molecular diagnostics and viral genomic sequencing to identify circulating virus types and variants. The researchers will also gather information about individual and household-level factors, including social and risk factors, to understand who is more likely to get sick despite vaccination.
Why it matters
Potential benefit: Findings could help doctors tailor vaccine guidance and public health steps so people at higher risk get better protection.
How similar studies have gone: Related vaccine effectiveness platforms have successfully tracked influenza and COVID-19 vaccine protection, and this project builds on those established methods.
Where this research is happening
-
University Hospitals of Cleveland
Cleveland, United States Active
Researchers
- Principal investigator: Saade, Elie — University Hospitals of Cleveland
- Study coordinator: Saade, Elie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.