Cleveland COPE-AKI care program for people recovering from severe acute kidney injury
Cleveland COPE-AKI Clinical Center
This project tests whether a nurse-led, doctor-supervised remote care pathway that closely manages blood pressure and protein in the urine can reduce long-term kidney problems for people who had severe acute kidney injury.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11136280 on NIH RePORTER |
What this research studies
If you survive a severe episode of acute kidney injury in the hospital, this program compares usual follow-up care with an intensive Champion Care Pathway led by a virtual nurse-navigator under a nephrologist's supervision. The team will regularly screen and closely monitor blood pressure and urine protein, use guideline-based medicines that affect the renin-angiotensin system, and optimize fluid management. Follow-up includes remote visits and coordinated care to try to catch and treat problems early. The goal is to lower the chance of progressing to chronic kidney disease, dialysis, or death, and to improve quality of life.
Who could benefit from this research
Good fit: Adults who were hospitalized with severe acute kidney injury (KDIGO stage 2 or 3) and are being discharged with ongoing concerns about blood pressure or protein in the urine are ideal candidates.
Not a fit: People who did not have severe AKI, whose kidney issues are unrelated to the AKI episode, or who already have optimal blood-pressure and proteinuria control may not gain benefit from this program.
Why it matters
Potential benefit: If successful, this approach could lower the risk of long-term kidney failure, improve patient-reported outcomes, and reduce healthcare costs.
How similar studies have performed: Treating high blood pressure and proteinuria is a proven way to slow chronic kidney disease, but applying an intensive, nurse-led remote care pathway specifically for AKI survivors is relatively new and not yet established.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Poggio, Emilio Daniel — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Poggio, Emilio Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.