Cleveland Alzheimer's clinical and registry program
Clinical Core
A Cleveland Clinic program that enrolls and follows older adults with Alzheimer’s-related dementias and cognitively normal volunteers (including people with the APOE e4 gene) to learn how the disease differs across individuals.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11167845 on NIH RePORTER |
What this research studies
If you join, the team will collect your medical history, cognitive testing results, and genetic information and will follow you regularly over time. They enroll people with mild cognitive impairment, typical Alzheimer’s dementia, dementia with Lewy bodies, and atypical/rapidly progressive Alzheimer’s, as well as cognitively normal older adults (many with APOE e4). The Clinical Core links participants to other research activities at the center, stores data securely, and prioritizes outreach to include underrepresented communities. Participation supports a registry that helps researchers design better future studies and trials.
Who could benefit from this research
Good fit: Older adults with mild cognitive impairment, Alzheimer’s-type dementia, dementia with Lewy bodies, atypical Alzheimer’s variants, or cognitively normal older adults (especially those with at least one APOE e4 allele) who can attend clinic visits and follow-up are ideal candidates.
Not a fit: People seeking an immediate treatment or cure, younger individuals without Alzheimer’s-related concerns, or those unable to attend in-person follow-up visits are unlikely to receive direct clinical benefit from participation.
Why it matters
Potential benefit: Participation could improve understanding of different Alzheimer’s types and help future diagnosis, trial matching, and personalized care.
How similar studies have performed: Longitudinal Alzheimer’s registries and cohort projects (for example ADNI and other center cohorts) have produced important findings, so this model is well-established and productive.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Appleby, Brian Stephen — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Appleby, Brian Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.