ClC-6 protein and blood pressure control
The Role of CIC-6 in Vascular Control of Blood Pressure
Researchers are looking at whether the ClC-6 protein in blood vessel muscle cells helps control blood pressure in adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11158786 on NIH RePORTER |
What this research studies
This project explores how a protein called ClC-6, found in the Golgi of vascular smooth muscle cells, might affect calcium handling and vessel contraction. Scientists will use cell-based experiments, advanced calcium imaging, and electrical measurements to study ClC-6 channel properties and its interaction with a Golgi calcium pump. Animal models will be used to see how loss or changes in ClC-6 influence blood vessel function and blood pressure. The work connects genetic findings about CLCN6 to basic mechanisms that could underlie hypertension and stroke risk.
Who could benefit from this research
Good fit: Adults with high blood pressure or a family history of hypertension would be most relevant to this line of research.
Not a fit: People under 21 or those whose blood pressure problems are caused by non-vascular issues are unlikely to benefit directly from this basic science work.
Why it matters
Potential benefit: If successful, this work could identify new targets for drugs or treatments to better control high blood pressure and lower stroke risk.
How similar studies have performed: Large genetic studies have linked CLCN6 to blood pressure and stroke risk, but functional studies of ClC-6 in blood vessels are largely new and this work is exploring previously untested mechanisms.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Klemens, Christine Anne — University of South Florida
- Study coordinator: Klemens, Christine Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.