Class I myosins influence how cells change shape and move.
Class I myosins regulate protrusive forces at the actin-membrane interface
This study is looking at how certain proteins help cells change shape and move, which is really important for things like our immune system and how cells take in nutrients, using simple models like yeast and immune cells from mice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10835903 on NIH RePORTER |
What this research studies
This research investigates the role of class I myosins, which are molecular motors that interact with actin filaments and cell membranes, in the processes that allow cells to change shape and move. By using model systems like fission yeast and murine macrophages, the researchers will explore how myosin activity affects the assembly of actin networks during critical cellular functions such as endocytosis and phagocytosis. The study aims to uncover the molecular mechanisms that drive these processes, which are essential for immune responses and cellular movement.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that affect cellular movement or immune responses, such as autoimmune diseases or certain cancers.
Not a fit: Patients with conditions unrelated to cellular motility or immune function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular movement and immune responses, potentially informing treatments for conditions related to cell motility and immune function.
How similar studies have performed: Other research has shown success in understanding cellular movement and immune responses through similar molecular approaches, indicating that this study builds on established knowledge.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Krendel, Mira — Upstate Medical University
- Study coordinator: Krendel, Mira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.