Circular RNA and Fertility
Circular RNA Role in Ovarian Follicular Development and Fertility
This research explores how tiny molecules called circular RNA affect ovarian development, which is important for fertility.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11175268 on NIH RePORTER |
What this research studies
Our ovaries go through many changes during the menstrual cycle, especially after a hormone surge that leads to ovulation. This project looks at circular RNA, which are a type of genetic material that helps control these changes, even though they are not well understood in the context of ovarian health. We are particularly interested in a protein called KHDRBS1, which appears to be important for making these circular RNAs and has been linked to fertility issues in animals. By understanding how KHDRBS1 and circular RNAs work together, we hope to learn more about the fundamental processes of fertility.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly but aims to benefit future patients experiencing infertility or ovarian development issues.
Not a fit: Patients not experiencing infertility or issues with ovarian development may not directly benefit from this specific basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the causes of infertility and potentially new ways to help people struggling to conceive.
How similar studies have performed: The role of circular RNA in ovarian development is relatively new and largely unexplored, making this a novel area of investigation.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Christenson, Lane K. — University of Kansas Medical Center
- Study coordinator: Christenson, Lane K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.