Circuit function of fast-spiking interneurons in the olfactory bulb
Official title: Circuit functions of fast-spiking interneurons in the main olfactory bulb
Funded at Lehigh University · NIH-11346013 · Data updated 2026-11-12
A study to understand how fast-spiking nerve cells in the brain’s smell center communicate to shape how smells are processed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lehigh University NIH-funded |
| Lab location | 1 site (Bethlehem, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $402,500 |
| NIH project number | 5R01DC021296-04 |
| Project ID | NIH-11346013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable here; preclinical neuroscience research using mouse brain tissue. No direct patient participation required.
✕Less likely to help
No direct benefit to patients; the work is in animals and fundamental neuroscience.
What this research studies
This project looks at how fast-spiking interneurons in the olfactory bulb influence the timing and coordination of neuron signals in the network that detects smells. Researchers will use recordings from mouse brain tissue to map unit-to-unit interactions between these interneurons and the main output cells. The goal is to uncover how these cells contribute to reliable smell coding and odor-guided behavior. Findings could illuminate basic brain function and how smell circuits may be disrupted in disease.
Why it matters
Potential benefit: Better insight into how the brain encodes smells, which could inform understanding of neural circuitry relevant to neurodegenerative diseases that affect memory and perception.
How similar studies have gone: Previous work shows that inhibitory interneurons shape neural timing; this study builds on established methods to link synaptic interactions with coding.
Where this research is happening
-
Lehigh University
Bethlehem, United States Active
Researchers
- Principal investigator: Burton, Shawn Denver — Lehigh University
- Study coordinator: Burton, Shawn Denver
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.