Chicago center for advanced heart testing and personalized care in heart failure
CHIcago Center for Accelerating nextGen Omics, deep phenotyping, and data science in Heart Failure (CHICAGO-HF)
['FUNDING_U01'] · NORTHWESTERN UNIVERSITY · NIH-11159721
This project uses detailed heart imaging, tissue samples, and modern genetic and data tools to find different types of heart failure in adults with HFpEF so future treatments can be more personalized.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11159721 on ClinicalTrials.gov |
What this research studies
If you have heart failure with preserved ejection fraction (HFpEF), this program will invite you to a series of detailed tests including heart MRI, blood and tissue sampling, and possible endomyocardial biopsy. Researchers will collect next-generation “omics” data (like genetics and molecular profiles) along with deep clinical information about other body systems and conditions. Advanced data science and AI methods will be used to group patients into biologically meaningful subtypes and identify potential targets for new treatments. This is an observational effort focused on building knowledge that could guide future personalized therapies rather than providing an immediate new treatment.
Who could benefit from this research
Good fit: Adults diagnosed with heart failure with preserved ejection fraction (HFpEF) who are able to participate in imaging, blood draws, and possible tissue sampling would be the ideal participants.
Not a fit: People without HFpEF (for example, those with reduced ejection fraction), children, or patients unable or unwilling to undergo imaging or biopsy may not directly benefit from this program.
Why it matters
Potential benefit: If successful, this work could lead to better ways to classify HFpEF and to tailored treatments that improve symptoms and outcomes for patients.
How similar studies have performed: Previous smaller studies using deep phenotyping and omics in HFpEF have suggested distinct subgroups and promise, but these approaches have not yet produced widely adopted, disease-modifying treatments.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHAN, SADIYA SANA — NORTHWESTERN UNIVERSITY
- Study coordinator: KHAN, SADIYA SANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.