Chemical tools to find and target cancer-related protein changes
Unlocking the Chemical Space of Cancer-Associated Perturbations
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11174292
Researchers are creating chemical probes that reveal how tumor proteins change so treatments can be better matched to people with cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11174292 on ClinicalTrials.gov |
What this research studies
This project will build a new platform called Probe Enabled Activity Reporting to measure dynamic changes in the proteins inside tumor cells. Scientists will combine chemistry and cancer biology to make and use small-molecule probes that tag active or altered proteins in cell lines and tumor samples. The work will map unique protein features that drive cancer behavior and that could point to new drug targets. Over time this approach aims to connect protein-level information with therapies that might work for specific tumors.
Who could benefit from this research
Good fit: People with cancer who can provide tumor tissue or who might join future trials based on protein-based profiling are the most relevant candidates.
Not a fit: Patients without cancer, those who cannot provide samples, or those whose tumors lack targetable protein changes are unlikely to gain direct benefit from this project.
Why it matters
Potential benefit: If successful, the platform could help identify new protein targets and guide more precise treatment choices for cancer patients.
How similar studies have performed: Related chemical-proteomics methods have shown promise in research settings, but this specific probe-enabled platform is a novel development.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRADY, DONITA C — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: BRADY, DONITA C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.