Chemical tags on RNA that control gene activity
Center for Genomic Information Encoded by RNA Nucleotide Modifications
Researchers are mapping chemical tags on rRNA, tRNA, and mRNA to understand how they change gene activity in human tissues and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11136985 on NIH RePORTER |
What this research studies
This project will create new laboratory and sequencing tools to read and quantify chemical modifications on the three main types of RNA (mRNA, tRNA, rRNA). The team will profile these RNA modifications across different tissues and disease samples to build maps of the proposed "RNA code." They will study how combinations of modifications influence RNA interactions and protein production using biochemical experiments and computational analysis. The work aims to make scalable methods so these maps can be compared across many samples and conditions.
Who could benefit from this research
Good fit: Ideal participants would be people willing to provide tissue or blood samples from conditions suspected to involve altered RNA regulation, such as certain cancers or neurological disorders.
Not a fit: Patients seeking immediate treatment changes are unlikely to benefit directly because this is early-stage basic research focused on mechanisms and tools.
Why it matters
Potential benefit: If successful, this work could reveal new disease mechanisms, point to diagnostic biomarkers, and identify molecular targets for future therapies.
How similar studies have performed: Prior studies of specific RNA marks (for example m6A) have shown effects on gene expression and disease, but comprehensive, cross-RNA-type mapping and interaction studies are still novel.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Jaffrey, Samie R — Weill Medical Coll of Cornell Univ
- Study coordinator: Jaffrey, Samie R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.