Characterization of ARIA in a squirrel monkey model of sporadic CAA using brain imaging and biomarkers
Official title: Characterization of ARIA by neuroimaging, proteomics, and neuropathology in a Squirrel monkey model of sporadic CAA
Funded at New York University School of Medicine · NIH-11502230 · Data updated 2026-11-12
A scientist team is studying how amyloid-related imaging abnormalities (ARIA) appear in a squirrel monkey model of cerebral amyloid angiopathy (CAA) to help make future AD therapies safer for people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $466,125 |
| NIH project number | 1R21NS153418-01 |
| Project ID | NIH-11502230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with Alzheimer's disease or related dementias, or those at risk of CAA/ARIA who may benefit from safer therapeutic approaches in the future.
✕Less likely to help
Patients without AD or CAA-related risks or those not participating in translational biomarker work may not directly benefit.
What this research studies
Researchers will use advanced brain scans, fluid biomarkers, and brain tissue studies in squirrel monkeys to understand ARIA and CAA together. They will look at MRI measures of brain structure and diffusion, and connect those findings with proteins in body fluids and brain pathology. This work aims to map how ARIA develops in relation to CAA, so future treatments for Alzheimer’s-related conditions can be guided to minimize risks. The study builds on prior monkey data and plans to validate diagnostic biomarkers that could reduce ARIA risk in humans.
Why it matters
Potential benefit: If successful, the project could help reduce ARIA risk and improve safety for AD therapies in people.
How similar studies have gone: Previous animal studies have shown promise in using multi-modal imaging and biomarkers to understand ARIA and CAA relationships.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Scholtzova, Henrieta — New York University School of Medicine
- Study coordinator: Scholtzova, Henrieta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.