Changing how immune cells use energy to stop memory loss and Alzheimer's disease
Reprogramming myeloid cell metabolism to prevent cognitive aging and Alzheimer's Disease
This study is looking at how getting older affects certain immune cells in the brain that help keep our thinking sharp, and it aims to find ways to boost these cells so they can better support our brain health and fight off problems like Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11051137 on NIH RePORTER |
What this research studies
This research focuses on understanding how aging affects immune cells in the brain and their role in cognitive decline and Alzheimer's disease. It investigates how myeloid cells, including microglia and macrophages, become dysfunctional with age, leading to increased risk of cognitive impairment. The researchers aim to reprogram the metabolism of these cells to restore their normal functions, which include supporting neurons and clearing harmful proteins. By enhancing the energy production in these immune cells, the study seeks to improve their ability to combat age-related cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's disease or those with advanced neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing down cognitive aging and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting immune cell metabolism to improve cognitive function, suggesting potential success for this approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Andreasson, Katrin I. — Stanford University
- Study coordinator: Andreasson, Katrin I.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.