Changing HIV proteins to improve vaccine responses
Modulating antigenic and immunogenic properties of HIV Env by altering signal sequence
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10576306
This study is looking at how changing certain parts of HIV proteins can help your immune system make better antibodies to fight the virus, which could lead to stronger vaccines for HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10576306 on ClinicalTrials.gov |
What this research studies
This research investigates how altering the signal sequence of HIV proteins can enhance the immune response to the virus. By modifying the signal sequence, the study aims to produce antibodies that are more effective at targeting HIV and triggering immune functions. The approach involves using different HIV isolates to create modified proteins that can induce a stronger and broader antibody response in immunized models. This could lead to the development of more effective vaccines against HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for HIV who are interested in participating in vaccine trials.
Not a fit: Patients who are already living with HIV or those who are not at risk for HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines that provide better protection against HIV infection.
How similar studies have performed: Previous research has shown promise in enhancing vaccine responses through similar modifications, indicating potential for success in this approach.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UPADHYAY, CHITRA — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: UPADHYAY, CHITRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.