Changing heart cells to repair heart damage
Altering Cardiac Cell Fate for Heart Repair
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10980563
This study is exploring a new way to help people with heart failure by turning certain heart-supporting cells into actual heart muscle cells, which could help repair damage from things like heart attacks and improve heart function.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10980563 on ClinicalTrials.gov |
What this research studies
This research investigates a new approach to treat heart failure by converting cardiac fibroblasts, which are cells that support heart structure, into functional heart muscle cells. The process involves delivering specific transcription factors that can reprogram these fibroblasts, potentially restoring heart function after damage such as a heart attack. The research builds on previous findings in animal models and aims to improve the methods for generating these new heart cells in humans, which could lead to better outcomes for patients with heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have experienced heart damage due to conditions like acute myocardial infarction and are suffering from heart failure.
Not a fit: Patients with non-cardiac related health issues or those whose heart damage is not due to myocardial infarction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a groundbreaking therapy for heart repair, significantly improving the quality of life for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in animal models for similar approaches, indicating potential for success in human applications.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QIAN, LI — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: QIAN, LI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders, cardiac injury