Changes in the optic nerve head may lead to scarring in glaucoma
Optic nerve head metabolic change promotes fibrosis
This study is looking at how changes in the optic nerve head can lead to scarring in people with glaucoma, and it aims to find ways to protect the important cells in the eye so they can stay healthy and work better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas Hlth Sci Ctr NIH-funded |
| Lab location | 1 site (Fort Worth, United States) |
| Project ID | NIH-10950983 on NIH RePORTER |
What this research studies
This research investigates how metabolic changes in the optic nerve head contribute to fibrosis, particularly in patients with glaucoma. It focuses on understanding the relationship between increased intraocular pressure and the resulting fibrotic response that can damage retinal ganglion cells. By exploring the metabolic pathways involved, the research aims to identify potential interventions that could prevent or reverse harmful fibrosis. The ultimate goal is to enhance the survival and function of retinal cells affected by glaucoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary open-angle glaucoma who are experiencing changes in their optic nerve head.
Not a fit: Patients with other types of glaucoma or those without any optic nerve head changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect vision by preventing scarring in the optic nerve head of glaucoma patients.
How similar studies have performed: While the specific approach of linking metabolism and fibrosis in the optic nerve head is novel, similar studies have shown promise in understanding fibrotic responses in other tissues.
Where this research is happening
Fort Worth, United States
- University of North Texas Hlth Sci Ctr — Fort Worth, United States (Active)
Researchers
- Principal investigator: Inman, Denise M — University of North Texas Hlth Sci Ctr
- Study coordinator: Inman, Denise M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.