Changes in the immune system and inflammation in SuperAgers
Immune and inflammatory system changes in SuperAgers
This study is looking at how changes in the immune and inflammatory systems might help SuperAgers—people who have amazing memory skills even as they get older—stay sharp and healthy in their brains, especially when it comes to fighting off infections and preventing memory loss or Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11082258 on NIH RePORTER |
What this research studies
This research investigates how immune and inflammatory system changes affect brain health and cognitive function in individuals known as SuperAgers, who maintain superior memory capabilities into older age. The study aims to understand the role of these systems in both responding to infections and influencing long-term brain health, particularly in relation to age-related cognitive decline and Alzheimer's disease. By examining unique individuals who exhibit exceptional memory performance, the research seeks to uncover the biological mechanisms that contribute to resilience against cognitive decline. This involves analyzing genetic risk factors and immune responses throughout the lifespan.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who demonstrate exceptional memory performance, known as SuperAgers.
Not a fit: Patients with significant cognitive impairment or advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and interventions that help preserve cognitive function in aging populations.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune and inflammatory processes in aging and cognitive health, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Huentelman, Matt — University of Chicago
- Study coordinator: Huentelman, Matt
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.