Changes in social thinking and understanding in adults with schizophrenia
Progression of Social Cognitive Deficits in Mid- and Late-Life Schizophrenia Spectrum Disorders
This project looks at how social understanding and related brain signals change with age in people with schizophrenia spectrum disorders to help guide better care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11258982 on NIH RePORTER |
What this research studies
You would be asked to complete interviews, questionnaires, and tasks that measure how you understand others, along with tests of thinking and daily functioning. About 192 people with schizophrenia-spectrum disorders aged 35–75 will be enrolled, plus 48 younger adults (18–34) with early psychosis and 120 healthy people of similar ages for comparison. Most participants (about 75%) will also do task-based EEG where a cap records brain activity during social thinking tasks. The researchers aim to link changes in social skills to age and brain signals so future treatments can be more targeted.
Who could benefit from this research
Good fit: Ideal candidates are adults with schizophrenia-spectrum disorders aged 35–75, with younger early-psychosis adults (18–34) and age-matched healthy volunteers included for comparison.
Not a fit: People without a schizophrenia-spectrum diagnosis or those unable to complete cognitive testing or EEG procedures (for example, due to severe movement disorders or inability to consent) may not directly benefit from this project.
Why it matters
Potential benefit: If successful, this work could help clinicians identify social thinking problems earlier and design brain-targeted treatments for middle-aged and older adults with schizophrenia.
How similar studies have performed: Prior studies have documented social cognitive problems in schizophrenia and some EEG markers of social processing, but combining a large, age-spanning clinical sample with task EEG is relatively novel.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Tso, Ivy Fei — Ohio State University
- Study coordinator: Tso, Ivy Fei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.