Changes in gut bacteria in patients with non-infectious uveitis
Official title: Longitudinal changes in the Gut Microbiota in Non-infectious Uveitis
Funded at University of Michigan at Ann Arbor · NIH-11033520 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut change over time if you have non-infectious uveitis, and it wants to see if these changes can go back to normal after treatment, helping us understand the link between gut health and eye inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $286,534 |
| NIH project number | 1K23EY036928-01 |
| Project ID | NIH-11033520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-infectious uveitis, particularly those experiencing active disease.
✕Less likely to help
Patients with infectious uveitis or those without any form of uveitis may not benefit from this research.
What this research studies
This research investigates how the gut microbiota, the community of bacteria in the digestive system, changes over time in patients with non-infectious uveitis (NIU). By comparing the gut bacteria of patients experiencing active disease to healthy individuals, the study aims to identify specific alterations associated with disease activity. The researchers will also explore whether these changes in gut bacteria can revert to normal following treatment. This longitudinal approach will provide insights into the relationship between gut health and eye inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing non-infectious uveitis by targeting gut microbiota.
How similar studies have gone: Previous research has shown promising results in understanding the gut microbiota's role in autoimmune diseases, suggesting potential for success in this area as well.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Kodati, Shilpa — University of Michigan at Ann Arbor
- Study coordinator: Kodati, Shilpa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.