Changes in brain cell communication after traumatic brain injury
Synaptic Vesicular Alterations after Traumatic Brain Injury
This study is looking at how a traumatic brain injury affects the way brain cells communicate with each other, especially focusing on tiny structures that help send messages between them, to find ways to improve thinking and memory for people who have had such injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10878822 on NIH RePORTER |
What this research studies
This research investigates how traumatic brain injury (TBI) affects the communication between brain cells, particularly focusing on the alterations in synaptic vesicles that are crucial for neurotransmission. By examining the role of clathrin light chains and the recycling of neurotransmitter vesicles, the study aims to understand the underlying mechanisms that lead to cognitive impairments following TBI. Using a rat model, researchers will analyze the changes in synaptic function over time after injury, which could provide insights into potential therapeutic targets for improving cognitive outcomes in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are facing cognitive challenges such as memory or attention difficulties.
Not a fit: Patients with cognitive impairments not related to traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for patients recovering from traumatic brain injuries.
How similar studies have performed: Previous studies have shown that understanding synaptic dysfunction in TBI can lead to significant advancements in treatment approaches, suggesting that this research builds on established findings.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Carlson, Shaun — University of Pittsburgh at Pittsburgh
- Study coordinator: Carlson, Shaun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.