Cervicovaginal microbiome and HPV persistence in Native American women
Full Project 1: Using Community-Engaged Research to Assess the Association of the Cervicovaginal Microenvironment and HPV Persistence and Clearance in Native American Women-
['FUNDING_OTHER'] · UNIVERSITY OF ARIZONA · NIH-11195133
This project looks at whether the bacteria and local environment in the cervix and vagina help human papillomavirus (HPV) stay or go away in Native American women.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11195133 on ClinicalTrials.gov |
What this research studies
This project partners with Native American communities to collect cervicovaginal samples and health information from women over time. Researchers use DNA-based 16S sequencing to map the vaginal bacteria and compare those patterns with whether HPV infection clears or persists. Community-engaged methods are used so the work reflects local perspectives and improves participation. The goal is to link microbiome features with HPV outcomes in a population often missing from past studies.
Who could benefit from this research
Good fit: Ideal candidates are Native American women who are willing to provide cervicovaginal samples and health information and who are receiving routine cervical screening or have known HPV infection.
Not a fit: People who are not Native American, cannot provide genital samples, or already have advanced invasive cervical cancer may not directly benefit from this project.
Why it matters
Potential benefit: If successful, the work could point to microbiome-based ways to prevent persistent HPV and reduce cervical cancer risk among Native American women.
How similar studies have performed: Previous studies have linked vaginal microbiota patterns to HPV persistence in other groups, but few have included Native American women, making this work partly confirmatory and partly novel for this population.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HERBST-KRALOVETZ, MELISSA MARIE — UNIVERSITY OF ARIZONA
- Study coordinator: HERBST-KRALOVETZ, MELISSA MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.