Cerebrospinal fluid drainage in babies with bleeding-related hydrocephalus
Assessing CSF flow dynamics in pediatric hemorrhagic hydrocephalus
This project looks at how cerebrospinal fluid drains in newborns who develop hydrocephalus after brain bleeding, and how drainage relates to inflammation and recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11324957 on NIH RePORTER |
What this research studies
If my baby joins, doctors will use a new, noninvasive imaging method called fluorescence cap-based transcranial optical tomography (fCTOT) to watch how cerebrospinal fluid moves between the brain ventricles and lymphatic drainage pathways. They will also collect biological markers of neuroinflammation and combine those results with brain imaging and clinical follow-up. The pilot aims to find patterns that predict which infants worsen and to point toward better ways to prevent long-term brain injury.
Who could benefit from this research
Good fit: Ideal candidates are premature newborns or infants who have had intraventricular hemorrhage and developed or are at risk for post-hemorrhagic hydrocephalus.
Not a fit: Older children, adults, or children whose hydrocephalus is caused by non-bleeding conditions are unlikely to benefit directly from this pilot.
Why it matters
Potential benefit: If successful, this could help clinicians spot babies at high risk for worsening hydrocephalus and guide treatments to prevent long-term brain damage.
How similar studies have performed: Animal and preclinical studies support a role for impaired lymphatic CSF outflow and inflammation in hydrocephalus, but using fCTOT imaging in human infants is a novel approach.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Sevick, Eva M. — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Sevick, Eva M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.