Central support for understanding immune aging
Administrative Core
['FUNDING_P01'] · STANFORD UNIVERSITY · NIH-11192805
This program builds a precise "immune-age" score from blood samples of adults, including middle-aged twins, to track how the immune system changes with age.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11192805 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, researchers collect blood and other samples to measure immune cell types, cytokines, and cell-specific epigenetic changes. They expand their cohort by adding 40–60-year-old twins to see how genetics and environment shape each person's position along a common immune-aging pathway. The team uses high-dimensional immune cell profiling and molecular tests to convert complex data into a single immune-age number for each person. Over time they will relate that immune-age to how people respond to infections or therapies to understand links between immune aging and clinical outcomes.
Who could benefit from this research
Good fit: Ideal participants are adults willing to provide blood samples and health information, especially middle-aged individuals (around 40–60 years old) and twins.
Not a fit: People seeking immediate treatment for an acute illness are unlikely to receive direct benefit because this is observational work focused on measurement development.
Why it matters
Potential benefit: If successful, this could help identify people whose immune systems age faster or slower than their years and guide preventive or personalized care strategies.
How similar studies have performed: Previous research has shown patterns of immune aging, but this project adds twin comparisons and multi-omic profiling to refine and validate a more precise immune-age metric.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVIS, MARK MORRIS — STANFORD UNIVERSITY
- Study coordinator: DAVIS, MARK MORRIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.