Central repository for brain scans, blood tests, and genetic data from people with white matter brain changes
Repository Core
This project collects and shares brain imaging, blood biomarkers, and genetic information from people with cognitive complaints and white matter changes to help researchers find causes and improve care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11320710 on NIH RePORTER |
What this research studies
You would contribute brain MRI scans, blood samples, and DNA data that are processed the same way across sites and stored in a central repository. The project enrolls a diverse group of about 2,250 people and collects data at three time points to track changes over time. Standardized quality control and data-sharing procedures are used so researchers across the U.S. can analyze the same high-quality information. The Repository Core handles collection, processing, storage, tracking, and controlled sharing of imaging, biospecimens, and genetic data.
Who could benefit from this research
Good fit: Adults with cognitive complaints and incidental white matter lesions on MRI who can provide blood samples, genetic consent, and attend baseline plus follow-up visits are the ideal candidates.
Not a fit: People without cognitive symptoms or without white matter changes on MRI, or those unwilling to give samples or return for follow-up, are unlikely to gain direct benefit from participating.
Why it matters
Potential benefit: If successful, this could help link imaging, blood markers, and genetics to cognitive decline and lead to earlier diagnosis and more targeted treatments.
How similar studies have performed: Large cohort and biorepository efforts (for example ADNI) have successfully identified biomarkers and enabled discoveries, and this project applies similar proven methods focused on diverse patients with white matter injury.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Jin, Lee-Way — University of California at Davis
- Study coordinator: Jin, Lee-Way
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.